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Dr. Sanders' research interests are in the interdisciplinary
areas of cancer biology and biological response modification. Studies
are currently focused on investigating the role of vitamin E compounds
as biological response modifiers of cancer cell growth, survival and metastasis.
Cellular and molecular processes involved in the action of vitamin E compounds
as tumor cell growth regulators and pro-death signals are under study.
Selected Publications
Yu, W., M-C. Shun, K. Anderson, H. Chen, B. G. Sanders, and K.
Kline. 2006. Alpha-TEA inhibits survival and enhances death pathways in
cisplatin sensitive and resistant human ovarian cancer cells. Apoptosis.
11: 1813-1823.
Anderson, K., K. A. Lawson, M. Simmons-Menchaca, L-Z. Sun, B. G. Sanders
and K. Kline. 2004. Alpha-TEA plus cisplatin reduces human cisplatin-resistant
ovarian cancer cell tumor burden and metastasis. Experimental Biology
and Medicine. 229: 1169-1176.
Lawson, K.A., K. Anderson, M. Menchaca, J. Atkinson, L-Z. Sun, B.
G. Sanders, and K. Kline. 2004. Comparison of vitamin E derivatives,
alpha-TEA and VES in reduction of mouse mammary tumor burden and metastasis.
Experimental Biology and Medicine. 229: 954-963.
Lawson, K. A., K. Anderson, R. M. Snyder, M. Simmons-Menchaca, J. Atkinson,
L-Z. Sun, A. Bandyopadhyay, V. Knight, B. E. Gilbert, B. G. Sanders
and K. Kline. 2004. Novel vitamin E analogue and 9-nitro-camptothecin
administered as liposome aerosols decrease syngeneic mouse mammary tumor
burden and inhibit metastasis. Cancer Chemotherapy and Pharmacology.
54: 421-431.
Zhang, S., K. A. Lawson, M. Simmons-Menchaca, L-Z. Sun, B. G. Sanders,
and K. Kline. 2004. Vitamin E analog alpha-TEA and celecoxib alone and
together reduce human MDA-MB-435-FL-GFP breast cancer burden and metastasis
in nude mice. Breast Cancer Research and Treatment. 87: 111-121.
Anderson, K., M. Simmons-Menchaca, K. A. Lawson, J. A. Atkinson, B.
G. Sanders and K. Kline. 2004. Differential response of human ovarian
cancer cells to induction of apoptosis by vitamin E succinate and vitamin
E analog, alpha-TEA. Cancer Research. 64: 4263-4269.
Shun, M-C., W. Yu, A. Gapor, R. Parsons, J. Atkinson, B. G. Sanders,
and K. Kline. 2004. Pro-apoptotic mechanisms of action of a novel vitamin
E analog (alpha-TEA) and a naturally occurring form of vitamin E (gamma-tocotrienol)
in MDA-MB-435 human breast cancer cells. Nutrition and Cancer.
48: 95-105.
Lawson, K.A., K. Anderson, M. Menchaca, J. Atkinson, L-Z. Sun, V. Knight,
B. E. Gilbert, C. Conti, B. G. Sanders, and K. Kline. 2003. Novel
vitamin E analogue decreases syngeneic mouse mammary tumor burden and
reduces lung metastasis. Molecular Cancer Therapeutics. 2: 437-444.
Yu, W., B. G. Sanders and K. Kline. 2003. RRR-alpha-tocopheryl
succinate-induced apoptosis of human breast cancer cells involves Bax
translocation to mitochondria. Cancer Research. 63: 2483-2491.
Yu, W., B. G. Sanders and K. Kline. 2002. RRR-alpha-tocopheryl
succinate induction of DNA synthesis arrest of human MDA-MB-435 cells
involves TGF-beta independent activation of p21 (Waf1/Cip1). Nutrition
and Cancer. 43: 227-236.
You, H., W. Yu, D. Munoz-Medellin, P. H. Brown, B. G. Sanders,
and K. Kline. 2002. Role of extracellular signal-regulated kinase pathway
in RRR-alpha-tocopheryl succinate-induced differentiation of human MDA-MB-435
breast cancer cells. Molecular Carcinogenesis. 4: 228-236.
You, H., W. Yu, B. G. Sanders, and K. Kline. 2001. RRR-alpha-tocopheryl
succinate induces MDA-MB-435 and MCF-7 human breast cancer cells to undergo
differentiation. Cell Growth & Differentiation. 12: 471-480.
Yu, W., Q. Y. Liao, F. M. Hantash, B. G. Sanders, and K. Kline.
2001. Activation of extracellular signal-regulated kinase and B-Jun-NH2-terminal
kinase but not p38 mitogen-activated protein kinases is required for RRR-alpha-tocopheryl
succinate-induced apoptosis of human breast cancer cells. Cancer Research.
61: 6569-6576.
Kline, K., W. Yu, and B. G. Sanders. 2001. Vitamin E: Mechanisms
of action as tumor cell growth inhibitors. Journal of Nutrition.
131: 161S-163S.
Israel, K., W. Yu, B. G. Sanders, and K. Kline. 2000. "Vitamin
E succinate (VES) induces apoptosis in human prostate cancer cells: Role
for Fas in VES-triggered apoptosis." Nutrition and Cancer.
36: 90-100.
Yu, W., K. Israel, Q. Y. Liao, M. Aldaz, B. G. Sanders, and K.
Kline. 1999. Vitamin E succinate (VES) induces Fas sensitivity in human
breast cancer cells: Role of Mr 43,000 Fas in VES-triggered apoptosis.
Cancer Research. 59: 953-961.
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