Dr. Perkins received her B.S. in biochemistry from North Carolina State University and her doctorate in physiology from the University of Virginia. She obtained further training in neuroendocrinology during postdoctoral fellowships at Stanford University (Department of Medicine) and the Johns Hopkins University (Department of Neuroscience). She was then recruited to the National Cancer Institute, first as a Senior Staff Fellow and then as an Investigator. From 2000-2006 she was Associate Director of the NCI Cancer Prevention Fellowship Program (CPFP). During her tenure there Dr. Perkins helped develop a hands-on laboratory course for CPFP Postdoctoral Fellows; created and maintained the Molecular Prevention Laboratory, a functional training laboratory for CPFP Fellows, located at NCI-Frederick; and, in addition to her own research, oversaw and coordinated the laboratory research activities of the Nutrition and Molecular Carcinogenesis Section, then headed by Dr. Stephen Hursting. Her research uses transgenic mouse models to study the interactions among nutritional factors, hormones, and genetic susceptibility to cancer.

Recent Publications

Lavigne JA, Takahashi Y, Chandramouli GV, Liu H, Perkins SN, Hursting SD, Wang TT. Concentration-dependent effects of genistein on global gene expression in MCF-7 breast cancer cells: an oligo microarray study. Breast Cancer Res Treat. 2007 Aug 9. [Epub ahead of print]

Fenton JI, Lavigne JA, Perkins SN, Liu H, Chandramouli GV, Shih JH, Hord NG, Hursting SD. Microarray analysis reveals that leptin induces autocrine/paracrine cascades to promote survival and proliferation of colon epithelial cells in an Apc genotype-dependent fashion. Mol Carcinog 47(1):9-21, 2008.

Rogers CJ, Berrigan D, Zaharoff DA, Hance KW, Patel AC, Perkins SN, Schlom J, Greiner JW, Hursting SD. Energy restriction and exercise differentially enhance components of systemic and mucosal immunity in mice. J Nutr 138(1):115-22, 2008.

Rogers CJ, Colbert LH, Greiner JW, Perkins SN, Hursting SD. Physical activity and cancer prevention : pathways and targets for intervention. Sports Med 38(4):271-96, 2008.

Moore T, Carbajal S, Beltran L, Perkins SN, Yakar S, Leroith D, Hursting SD, Digiovanni J. Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels. Cancer Res 68(10):3680-8, 2008.

Nuñez NP, SN Perkins, NCP Smith, D Berrigan, DM Berendes, L Varticovski, JC Barrett, SD Hursting. Obesity accelerates mouse mammary tumor growth in the absence of ovarian hormones. Nutr Cancer (in press).

Wang TTY, TS Hudson, T-C Wang, CM Remsberg, NM Davies, Kim, H Seifried, BT Vinyard, SN Perkins, SD Hursting. Differential effects of resveratrol on androgen-responsive LNCaP human prostate cancer cells in vitro and in vivo. Carcinogenesis (in press).

Eng-Wong J, SN Perkins, M Bondy, D Li, E Singletary, N Núñez, SD Hursting, S Chang. Premenopausal breast cancer: estrogen receptor status and insulin-like growth factor-I (IGF-I), insulin-like growth factor binding protein-3 (IGFBP-3) and leptin. Breast J (in press).

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