Dr. Kline's research interests are in the interdisciplinary areas of nutrition and cancer biology. Long term goals are to better our understanding of the biological actions of vitamin E, both naturally occurring forms and synthetic derivatives of vitamin E. Current investigations involve understanding the role of certain vitamin E compounds as tumor cell growth inhibitors. Cellular, biochemical and molecular mechanisms of vitamin E's actions in inhibiting cell proliferation and stimulating programmed cell death (apoptosis) are under study.

Selected Publications

Yu, W., M.C. Shun, K. Anderson, H. Chen, B.G. Sanders and K. Kline. 2006. Alpha-TEA inhibits survival and enhances death pathways in cisplatin sensitve and resistant human ovarian cancer cells. Apoptosis. 11: 1813-1823.

Anderson, K., K. A. Lawson, M. Simmons-Menchaca, L-Z. Sun, B. G. Sanders and K. Kline. 2004. "Alpha-TEA plus cisplatin reduces human cisplatin-resistant ovarian cancer cell tumor burden and metastasis." Experimental Biology and Medicine. 229: 1169-1176.

Kline, K. W. Yu and B. G. Sanders. 2004. Vitamin E and Breast Cancer. Journal of Nutrition. 134: 3458S-3462S

Lawson, K.A., K. Anderson, M. Menchaca, J. Atkinson, L-Z. Sun, B. G. Sanders, and K. Kline. 2004. "Comparison of vitamin E derivatives, alpha-TEA and VES in reduction of mouse mammary tumor burden and metastasis." Experimental Biology and Medicine. 229: 954-963.

Lawson, K. A., K. Anderson, R. M. Snyder, M. Simmons-Menchaca, J. Atkinson, L-Z. Sun, A. Bandyopadhyay, V. Knight, B. E. Gilbert, B. G. Sanders and K. Kline. 2004. "Novel vitamin E analogue and 9-nitro-camptothecin administered as liposome aerosols decrease syngeneic mouse mammary tumor burden and inhibit metastasis." Cancer Chemotherapy and Pharmacology. 54:421-431.

Zhang, S., K. A. Lawson, M. Simmons-Menchaca, L-Z. Sun, B. G. Sanders, and K. Kline. 2004. "Vitamin E analog alpha-TEA and celecoxib alone and together reduce human MDA-MB-435-FL-GFP breast cancer burden and metastasis in nude mice." Breast Cancer Research and Treatment. 87:111-121.

Anderson, K., M. Simmons-Menchaca, K. A. Lawson, J. A. Atkinson, B. G. Sanders and K. Kline. 2004. "Differential response of human ovarian cancer cells to induction of apoptosis by vitamin E succinate and vitamin E analog, alpha-TEA." Cancer Research. 64:4263-4269.

Yu, W., B. G. Sanders and K. Kline. 2003. "RRR-alpha-tocopheryl succinate-induced apoptosis of human breast cancer cells involves Bax translocation to mitochondria." Cancer Research. 63: 2483-2491.

Lawson, K.A., K. Anderson, M. Menchaca, J. Atkinson, L-Z. Sun, V. Knight, B. E. Gilbert, C. Conti, B. G. Sanders, and K. Kline. 2003. "Novel vitamin E analogue decreases syngeneic mouse mammary tumor burden and reduces lung metastasis." Molecular Cancer Therapeutics. 2: 437-444.

Yu, W., B. G. Sanders and K. Kline. 2002. "RRR-alpha-tocopheryl succinate induction of DNA synthesis arrest of human MDA-MB-435 cells involves TGF-beta independent activation of p21 (Waf1/Cip1)." Nutrition and Cancer. 43: 227-236.

You, H., W. Yu, D. Munoz-Medellin, P. H. Brown, B. G. Sanders, and K. Kline. 2002. "Role of extracellular signal-regulated kinase pathway in RRR-alpha-tocopheryl succinate-induced differentiation of human MDA-MB-435 breast cancer cells." Molecular Carcinogenesis. 4: 228-236.

You, H., W. Yu, B. G. Sanders, and K. Kline. 2001. "RRR-alpha-tocopheryl succinate induces MDA-MB-435 and MCF-7 human breast cancer cells to undergo differentiation." Cell Growth & Differentiation. 12: 471-480.

Yu, W., Q. Y. Liao, F. M. Hantash, B. G. Sanders, and K. Kline. 2001. "Activation of extracellular signal-regulated kinase and c-Jun-NH2-terminal kinase but not p38 mitogen-activated protein kinases is required for RRR-alpha-tocopheryl succinate-induced apoptosis of human breast cancer cells." Cancer Research. 61: 6569-6576.

Kline, K., W. Yu, and B. G. Sanders. 2001. Vitamin E: Mechanisms of action as tumor cell growth inhibitors. Journal of Nutrition. 131: 161S-163S.

Israel, K., W. Yu, B. G. Sanders, and K. Kline. 2000. "Vitamin E succinate (VES) induces apoptosis in human prostate cancer cells: Role for Fas in VES-triggered apoptosis." Nutrition and Cancer. 36: 90-100.

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