Dr. Fisher participates in the team teaching of several courses at UT-Austin and at Science Park, including GSBS 120144 (Science Park): Introduction to Pathology, GSBS 4.41.4 (Science Park): Basic Concepts in Tumor Biology, and PHR 2.390N (UT-Austin): Biochemical Toxicology.
        The research in Dr. Fischer's laboratory is primarily concerned with elucidating the role of inflammatory processes in the tumor promotion stage of multistage skin carcinogenesis. The emphasis of this work is on mediators of inflammation, including arachidonic acid metabolites, cytokines and growth factors and reactive oxygen species. She is involved in projects to determine the regulation of several of these mediators, especially prostaglandins, at the molecular level and in projects to determine their biological function in normal and tumor tissue. This information will be used to design chemoprevention strategies.

Research Interests

Skin and prostate tumor development: role & regulation of arachidonic acid metabolism and transforming growth factor beta involvement; development of animal models and strategies for cancer prevention.

Selected Publications:

Fischer, S.M., Conti, C.J., Lubet, R.A., Aldaz, C.M. and Viner, J. Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice. Carcinogenesis, 24:945-952, 2003.

Sabichi, AL, Fischer, SM, Zou, CC, Yang, X, Steele, VE, Kelloff, GJ, Lotan, R, Clifford, JL,. Retinoid receptor-dependent and independent biological activities of several novel phenretinamide analogs and metabolites. Clinical Cancer Res. 9:4606-4613, 2003.

Shureiqi, I., Jiang, W., Zuo, X.,.Wu, Y., Stimmel, J.B., Leesnitzer, L.M., Morris, J.S., Fan, H-Z, Fischer, S.M., Lippman, S.M. The 15 lipoxygenase product 13-HODE downregulates PPAR- to induce apoptosis in colorectal cancer cells. Proc. Natl. Acad. Sci. 100:9968-9973, 2003.

Kim, E., Muga, S.J., Fischer, S.M. Identification and characterization of a phorbol ester-response element in the murine 8S-lipoxygenase gene. J. Biol. Chem. 279:11188-11197, 2004.

Yang, P, Chan, D, Felix, E, Cartwright, C, Menter, DG, Madden, T, Klein, RD, Fischer, SM, Newman, RA. Formation and anti-proliferative effect of prostaglandin E3 from eicosapentaenoic acid in human lung cancer cells. J. Lipid Res. 45:1030-1039, 2004.

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