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Henry P. Ciolino graduated from the University of New
Orleans and earned a doctorate in Anatomy from the Louisiana State University
Medical School. Following a postdoctoral fellowship at the National Heart,
Lung, and Blood Institute, he served as Staff Scientist in the Center
for Cancer Research at the National Cancer Institute. Dr. Ciolino's research
focuses on elucidating the mechanisms responsible for the protective effect
of diets rich in fruits and vegetable on chronic diseases such as cancer
and heart disease. The goal of his studies is to further our understanding
of how dietary components exert their protective effects and to identify
promising new preventive regimens.
Recent Publications
Ciolino, H.P., MacDonald, C.J., Menon, O., Dankwah, M., and Yeh,
G.C. Dehydroepiandrosterone inhibits the expression of carcinogen-activating
enzymes in vivo. Int. J. Cancer, 105: 321-325. 2003.
Trapani, V., Patel, V., Leong, C.O., Ciolino, H.P., Yeh, G.C.,
Hose, C., Trepel, J.B., Stevens, M.F., Sausville, E.A., and Loaiza-Perez,
A.I. DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole
(5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient
MCF-7 cells. Br. J. Cancer. 88: 599-605, 2003.
MacDonald, C.J., Ciolino, H.P., and Yeh, G.C. The drug salicylamide
is an antagonist of the aryl hydrocarbon receptor that inhibits signal
transduction induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Cancer
Res. 64: 429-434, 2004.
Loaiza-Perez, A.I., Kenny, S., Hollingshead, M., Alley, M.C., Hose,
C., Ciolino, H.P., Yeh, G.C., Trepel, J.B., Vistica, D., and Sausville,
E.A. Aryl hydrocarbon receptor activation of an antitumor aminoflavone:
basis of selective toxicity for MCF-7 breast tumor cells. Mol Cancer
Ther. 3: 715-725, 2004.
Brantley, E., Patel, V., Stinson, S., Trapani, V., Hose, C.D., Ciolino,
H.P., Yeh, G.C., Sausville, E.A., and Loaiza-Perez, A.I. Antitumor
2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786)
induces NF-kB activity in drug sensitive MCF-7 cells. Anti-Cancer Drugs
16: 137-143, 2005.
Ciolino, H.P., McDonald, C.J., Menon, O., Bass, S.E., and Yeh,
G.C. Sulindac regulates the aryl hydrocarbon receptor-mediated expression
of Phase 1 metabolic enzymes in vitro and in vivo. Carcinogenesis,
2006, March 10; [E-pub ahead of print].
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