Dr. Matjasko's research focuses on the development of at-risk adolescents and the factors that promote their health and well-being. Her research emphasizes the use of ecological, lifecourse, and person-centered approaches in understanding the relationship between individual, family, school, and community factors and adolescent functioning. Current projects include an evaluation of the impacts of school-based prevention programs have on at-risk adolescent development; an investigation of the relationship between maternal work status, mental health, and parenting and their influences on adolescent functioning; and, the influence of parental divorce during childhood and adolescence on young adults' future family plans and values. She is a research affiliate with the Population Research Center at the University of Texas, the Sloan Center on Parents, Children, and Work, and the Northwestern University/University of Chicago Joint Center for Poverty Research.

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